Özet:

In this study was investigated on the effects on the some biochemical and histopathological parameters in plasma and liver tissue of Taraxacum officinale ethanol extract of paracetamol induced hepatotoxicity in rats. In this study was used 36 Sprague Dawley male rats, aged 5 months. Rats were divided 6 groups of 6 rats each, randomly. Animals of paracetamol administered were fasted 24 hours and 2 g/kg peros (p.o) Paracetamol was given after the 1 hour extract was given. 1.Group Control 5% DMSO intraperitoneal (i.p), 2. Group TOE1 200 mg/kg/day/i.p Taraxacum officinale extract (TOE) was dissolved in 5% DMSO in distilled water, i.p., 3. Group TOE2 250 mg/kg/day/i.p Taraxacum officinale extract. Group money 2 g/kg/p.o. The Paracetamol 5. Group PTOE1; Paracetamol 2 g/kg/day/p.o. + TOE 200 mg/kg/day/i.p. Group PTOE2 Paracetamol 2 g/kg/day/p.o.+ TOE 250 mg/kg/day/i.p were administered for 8 days. At the end of the study biochemical and histopatological analyses were made from samples of blood and liver tissue. Plasma AST, ALT, ALP, MDA, CAT and Nitrite levels; liver tissue Nitrite and Nitrate levels were increased (P<0.001); plasma GSH (P<0.001), SOD (P<0.001) and GPx levels (P<0.05); liver tissue GSH, CAT, and SOD levels (P<0.001) were decreased significantly in paracetamol group compared with control group. Paracetamol in rats formed hepatotoxicity Taraxacum officinale Wig. Aerial part made from ethanol as extract is used TOE 100 mg/kg of the amount of hepatotoxicity significantly decreased and prevented lipid peroxidation. Toxic effect was determined in animals administered TOE 250 mg/kg. Even if the obtained extract had positive effects on hepatotoxicity and biochemical parameters in liver and plasma, it was concluded that it was needed to repair the damage of the liver.

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