Özet:

The purposes. The aim of this study is to compare the effectiveness of 400 μg and 200 μg of misoprostol, which is administered orally and vaginally every six hours at the end of the second trimester pregnancy. The Method. In our planned study in the form of a backward file review, the effectiveness of misoprostol treatment protocols that are being applied in our clinic has been studied. A total of sixteen women between the ages of 18-43 were evaluated, where the second trimester of pregnancy was planned to end. 33 patients (group 1) were given 200 μg orally and 200 μg vaginal misoprostol repeated in 6 hours intervals. 27 patients (group 2) were given 100 μg orally and 100 μg vaginal misoprostol repeated in 4 hours intervals. Extrusion criteria were systemic illness, cervical surgery history, bleeding or leakage during current pregnancy. The dose is repeated in both groups until sufficient uterine contraction is achieved. If it wasn’t reduced in 48 hours, the method was considered unsuccessful. The findings. The average induction low range in Group 2 was found to be significantly shorter than in Group 1 (16.6±8.8 hours while 10.3±7.8 hours) (p<0.05). The average total dose of misoprostol used in Group 2 was found to be significantly lower than in Group 1 (p<0,05). No side effects have been detected in the groups. The result. The low dose of misoprostol, frequently administered at the end of the second trimester, has been found to be more effective than the high dose administered at long intervals. Keywords: fetus, misoprostol, second trimester, abstract ending pregnancy. To compare the effectiveness of 400 μg and 200 μg misoprostol administered by vaginal and oral route, repeated every six hours and four hours, respectively for second trimester pregnancy termination. The Methods. In this study, which is a retrospective file review, we evaluated the effectiveness of misoprostol treatment protocols used in our clinic. Medical files of a total of sixty women, aged 18-43 years, who was planned to have terminated second trimester pregnancy, were evaluated. Thirty three patients (group 1) received 200 μg oral and 200 μg vaginal misoprostol, repeated every 6 hours. Twenty seven patients (group 2) received 100 μg oral and 100 μg vaginal misoprostol, repeated every 4 hours. Exclusion criteria were systemic disease, a history of cervical operations, bleeding or spotting during the current pregnancy. If abortion did not occur within 48 hours, the treatment was considered to be failed. The results. The average induction-abortion interval of the group 2 was found to be significantly shorter than of the group 1 (16.6±8 h versus 10.3 ±7.9 h). The average total dose of misoprostol of group 2 was significantly lower than of group 1 (group 1, 1200±529μg; group 2, 622±390 μg). There were no side effects in the groups. and Conclusion. It was found that lower doses of misoprostol repeated in short intervals were more effective than of the higher doses repeated in long intervals. Key words: Fetus, misoprostol, second trimester, pregnancy termination.

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