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Amaç: Sık görülen hastalıklardan olan demir eksikliği anemisinin (DEA) küresel prevalansı %24,8 diabetes mellitusun (DM) ise %8,8’dir. DM’nin tanı ve takibinde kullanılan HbA1c, DEA varlığında açlık kan şekeriyle korelasyon göstermeyebilir. Araştırmanın amacı tip 2 DM’li hastalarda DEA tedavisinin HbA1c üzerindeki etkisini değerlendirmektir. Gereç ve Yöntem: Çalışmaya dâhil edilen hastalar en az bir yıldır DM tanısı olan ve düzenli ilaç kullanan bireylerdir. DM’si olup DEA’sı olmayan 61 birey kontrol grubunu DM ve DEA birlikte görülen 33 birey hasta grubunu oluşturmaktadır. Tüm hastaların ilk karşılaşmada hemoglobin, demir, ferritin, açlık kan şekeri ve HbA1c düzeyleri ölçülerek kaydedilmiştir. DEA’sı olan gruba mevcut DM tedavilerine devam ederken demir tedavisi başlanmış ve üç ay sonra tüm hastalar kontrole çağrılarak laboratuvar değerleri tekrar ölçülmüştür. Bulgular: Katılımcıların 63’ü kadın, 31’i erkekti yaş ortalaması 59,93’tü. Katılımcılardan DEA’sı olanların anemilerini tedavi etmeden önce HbA1c ortalaması 6,68±1,11 iken üç ay demir tedavisi aldıktan sonra HbA1c ortalaması 6,58±0,93’e gerilemişti. Kontrol grubundaki bireylerin ilk HbA1c ortalamaları 6,38±0,78 iken, üç ay sonraki ölçümlerde 6,37±0,78 olarak bulunmuştur. Sonuç: Diyabet tanı ve takibinde kullanılan HbA1c başta demir eksikliği olmak üzere pek çok metabolik durumdan etkilenebilir. Bu nedenler açlık kan şekeri ile uyumsuz HbA1c varlığında düşünülmelidir. Ancak konu hakkında daha geniş kapsamlı araştırmaların yapılması gereklidir.
The global prevalence of iron deficiency anemia (DEA) among common diseases is 24.8% and diabetes mellitus (DM) is 8.8%. The HbA1c used in the diagnosis and tracking of DM may not be correlated with hunger blood sugar in the presence of DEA. The aim of the study is to evaluate the effect of DEA treatment on HbA1c in patients with type 2 DM. Tools and Methods: The patients involved in the study are individuals who have been diagnosed with DM for a year and who regularly take medications. The control group of 61 individuals without the DM and the DEA; the control group of 33 individuals with the DM and the DEA together. In the first encounter of all patients, hemoglobin, iron, ferritin, hunger blood sugar and HbA1c levels were recorded by measuring. While the group with DEA continued to the existing DM treatments, iron therapy began and three months later the laboratory values were re-measured by calling all patients to check. Results: 63 of the participants were women, 31 were men; the average age was 59.93. The HbA1c average was 6.68±1.11 before the treatment of anemia of those with DEA from the participants, while the HbA1c average dropped to 6.58±0.93 after three months of iron treatment. The first HbA1c average of individuals in the control group was 6.38 ± 0.78, while in the three months following measurements it was 6.37 ± 0.78. The result: HbA1c used in the diagnosis and tracking of diabetes may be affected by many metabolic conditions, primarily iron deficiency. These causes should be considered in the presence of uncompatible HbA1c with hunger blood sugar. However, more comprehensive research on the subject is needed.
Objective: The global prevalence of iron deficiency anemia (IDA), one of the common diseases, is 24.8%, while prevalence of diabetes mellitus is 8.8%. HbA1c used in the diagnosis and follow-up of diabetes mellitus (DM) may not correlate with fasting blood sugar in iron deficiency anemia. The aim of the study was to evaluate the effect of iron deficiency anemia treatment on HbA1c in patients with type 2 DM. Methods: Patients included in the study were the individuals who have been diagnosed with DM for at least one year and are taking regular medication. Sixty one individuals with DM without iron deficiency anemia constitute the control group; DM and iron deficiency anemia together 33 individuals constitute the patient group. Hemoglobin, iron, ferritin, fasting blood sugar and HbA1c levels were recorded in the first encounter of all patients. The group with iron deficiency anemia continued with existing DM treatments and iron treatment was measured and after three months, all patients were called for control and their laboratory values were measured again. Results: Sixty three of the participants were female and 31 were male; the average age was 59.93. Before the treatment of iron deficiency anemia among the participants, the mean HbA1c was 6.68±1.11, and after three months of iron deficiency treatment, the mean HbA1c decreased to 6.58±0.93. While the average of the first HbA1c of the individuals in the control group was 6.38 ± 0.78, it was found as 6.37 ± 0.78 in the measurements after three months. Conclusion: HbA1c, used in the diagnosis and follow-up of diabetes, can be affected by many metabolic conditions, especially iron deficiency. These conditions should be considered in the presence of HbA1c incompatible with fasting blood sugar. However, further research is needed on the subject.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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