Abstract:

Polycystic over syndrome (PKOS) is a common endocrine disorder characterized by chronic anovulation and hyperandrogenism, affecting 5-10% of women in the reproductive age. It is intended to study and compare serum urocortin 2 and urocortin 3 and antimyleric hormone (AMH) levels in adolescents with healthy controls. To study, according to Rotterdam criteria, PKOS diagnosis (medium age: 16.1 ± 0.98 years) was taken from 37 and 39 healthy (medium age: 16.1 ± 1.08) controls from 76 adults. Anthropometric measurements of all patients and puberal development stages were recorded. Modified Ferriman-Gallwey score system has made a hirsutic score. The Homa-IR value >4 was considered as insulin resistance. By bioelectric impedance analysis, the body fat-muscle ratio of the facts was assessed. The level of hunger serum glucose, insulin, lipite, follicle stimulating hormone, luteinizing hormone, sex hormone binding globulin, free testosterone, total testosterone was measured. The USG and PKOS diagnosed facts over morphologies were evaluated. Results: There is no difference between the two groups in terms of average age (p>.05). In the PKOS group, the VKI SDS, the size SDS and the back circle were found higher than the SDS control group (p<.05). Obesity, acne, alopecia, acantosis, stria, oligo-amonere and hirsutizm scores were statically significantly high in the PKOS group (p<.01). There was no difference between the two groups in terms of the levels of AMH and urocortin 2-3 (p>.05). There is no relationship between the severity of Hirsutism and AMH between the levels 2 and 3 of urocortin (p>.05). While a significant positive correlation between AMH, urocortin 2 and urocortin 3 was detected, there was no correlation between LH, FSH, free testosterone, total testosterone and SHBG levels and AMH, urocortin 2 and urocortin 3 levels. Result: In this study, the relationship between urocortin 2 and urocortin 3 and AMH levels and PKOS was not found. More work is needed on this. Objective: Polycystic ovarian syndrome (PCOS) is a frequent endocrine disorder characterized by chronic anovulation and hyperandrogenism, affecting 5 to 10 percent of women in reproductive age. It was aimed in this study to examine serum urocortin 2, urocortin 3 and AMH levels in adolescents with PCOS and to compare the results with those of healthy adolescents. Material and Methods: 37 adolescent girls (16.1±0.98 years) with PCOS diagnosed according to Rotterdam criteria and 39 healthy adolescent girls (16.1±1.08 years) were recruited to the study. All patients' anthropometric measurements and pubertal development stages were recorded. Hirsutism was scored according to Ferriman-Gallwey scoring system. Insulin resistance was diagnosed when HOMA-IR was >4. Bioelectrical impedance analysis was used to measure body fat percentage and fat free mass. Levels of fasting glucose, insulin, lipids, follicle stimulating hormone, luteinizing hormone, sex hormone binding globulin, free and total testosterone, urocortin 2 and 3, and AMH were measured. Suprapubic pelvic USG was also performed in the PCOS group. Findings: The average age of the two groups was similar (p>.05). In the PCOS group, body mass index SDS, height SDS and waist circumference SDS was significantly higher than the control group (p<.05). Obesity, acne, alopecia, acanthosis, stria, oligomenorrhea and hirsutism score were significantly higher in the PCOS group (p<.01). AMH, urocortin 2 and urocortin 3 levels showed no significant difference between the two groups (p>.05). There was no significant correlation between hirsutism score and AMH, urocortin 2 and urocortin 3 levels (p>.05). There was a significant positive correlation between AMH, urocortin 2 and urocortin 3, but no correlation was found between LH, FSH, free testosterone, total testosterone, SHBG levels and AMH, urocortin 2 and urocortin 3. Conclusion: This study did not find any relationship between urocortin 2, urocortin 3 and AMH levels and PCOS. Further studies are needed to search about this topic.

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