Özet:

Introduction: Diarrhea is still a considerable health problem today, especially in developing countries, including Indonesia. One common etiology of diarrhea is Vibrio cholerae, which still causes many problems, such as inappropriate use of antibiotics causes antibiotic resistance. The golden sea cucumber (Stichopus hermanii) has antibacterial potential against Vibrio cholera. This study aims to determine the effect and lethal concentration of golden sea cucumber extract on the growth of Vibrio cholerae bacteria. Methods: This research is an experimental laboratory using the post-test-only control group design method. Dilution is conducted, where six groups are consisting of 4 treatment groups and two control groups. The concentration of the treatment group is 100%, 50%, 25%, and 12.5%, while for positive control using tetracycline and distilled water as a negative control. Results: The results of this study indicate that the extract of golden sea cucumbers can inhibit the growth of Vibrio cholerae bacteria, as evidenced by a dilution test, where the higher the concentration of the golden sea cucumber extract, the more Vibrio cholerae bacteria are inhibited its growth. With a value of p = 0.001. The lethal concentration of golden sea cucumber extract obtained from this study through a dilution test starting from a concentration of 25%. Conclusion: Golden sea cucumber extract (Stichopus hermanii) can inhibit the growth of Vibrio cholerae bacteria through dilution test, regardless of concentration.

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