Abstract:

Purpose: A specific phosphodiesterase-5 (PDE5) inhibitor, Tadalafil has well-known vazoactive effects as well as antioxidant effects. In this study, the possible protective effect of tadalafil in increased oxidative stress caused by unilateral ovarian obstruction in the kidneys was studied. Methods: 2.5-3 months Sprague-Dawley male rats are divided into 5 groups (n=8); sham (S), partial obstruction (P), P+Tadalafil (PT), complete obstruction (K) and K+Tadalafil (KT). PT and KT groups were given a single dose of tadalafil (10 mg/kg, ig) immediately before surgery. The victims were sacrificed 24 hours after the obstruction. In renal homogenates, MDA, AOPP levels and SOD and CAT activities have been studied. The level of serum creatine is also measured as a renal function indicator. Results: Both partial and complete obstruction has caused statistically significant increase in serum creatine values, kidney MDA and AOPP levels. Although there was no major change in SOD activity, CAT activity has decreased in both P and K groups. Compared to obstruction groups, tadalafil treatment has not caused significant changes in serum creatine, tissue MDA, AOPP levels and SOD activity. However, CAT activity was high in groups treated with tadalafil. The single dose of tadalafil in the PT group made it possible for CAT activity to return to control values. The result: Tadalafil has not seen a significant effect on the increased renal oxidative stress caused by one-sided partial and complete producer obstruction. However, the rise in CAT activity in the PT group to control values suggests that the duration of tadalafil treatment or increases in dose may be protective for the kidneys in UUO.

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