Özet:

In this study, neurotoxic effects of cigarette on prefrontal cortex and protective effects of caffeic acid phenetyl ester (CAPE) against these toxic effects were investigated at light microscopic level. For this purpose, 21 male Wistar rats were divided into three groups. Animals in Group I were used as control. Rats in Group II were exposed to cigarette smoke. The rats in Group III were exposed to cigarette smoke and injected daily with CAPE. At the end of the 60-days experimental period, all rats were killed by decapitation. Then the brains of rats were removed. Following routine histological procedures, the prefrontal cortex tissue specimens fixed in 10% formaldehyde were examined under a light microscope. Light microscopic examination of prefrontal cortex specimens from rats exposed to cigarette smoke revealed that vacuolization, neuroglial cell infiltration and pycnotic cells in the molecular layer. Whereas, exposure of cigarette smokeinduced structural changes were decreased in rats exposed to cigarette smoke and injected with CAPE, but only pycnotic cells were seen similar to the cigarette smoke group. In conclusion, It was determined that exposure to cigarette smoke caused damage in prefrontal cortex of rats and this damage was prevented by administration of CAPE

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