Özet:

Ten proton transfer salts (9-18) were synthesized from the reaction of 2-aminopyridine (1), 2-amino-3/4/5/6-methylpyridines (2-5) and 3-aminomethylpyridine (6) with (E)-3-(3/4-sulfamoylphenylcarbamoyl)acrylic acid (7 and 8), respectively. Bacillus subtilis (wild culture), Candida albicans (ATCC 14053) (yeast), Enterococcus faecalis (ATCC 29212) (Gram positive), Escherichia coli (ATCC 25922), Listeria monocytogenes (ATCC 7644), Pseudomonas aeruginosa (ATCC 27853), Staphylococcus aureus (NRRL B-767) (Gram negative) bacterial microorganisms have been tested against the antimicrobial evaluation of compounds (1–18). Vancomycin, Cefepime, Levofloxacin and the antifungal substance Fluconazole were used as antibacterial reference compounds for comparing the MIC values of 1-18. Compounds 1, 3-6, 8-13, 15, 17 and 18 for E. faecalis, 5 for B. subtilis, 1, 3-12, 15, 17 and 18 for S. aureus, 3, 9, 10, 13, 15 and 17 for L. monocytogenes, 16 for E. Coli and 4 for P. aeruginosa the best effect are observed. Proton transfer salts {9, 14, 15 and 17} were showed higher effect than Fluconazole while other compounds (except compounds 2 and 4) had similar effects with Fluconazole. The compounds 2 and 4 showed less activity than Fluconazole.

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