Özet:

Purpose: The aim of this study is to make an assessment by measuring the levels of CRP, seruloplasmine and TAS (total antioxidant level), TOS (total oxidant level), OSI (oxidative stress index) in the serum taken at certain intervals from patients who entered the cardiopulmonary bypass (KPB) surgery. Methods: A working group was formed by taking blood from patients with KPB surgery for a variety of reasons, including 4 jelly-free tubes before surgery, entrance to the pump (heart pulmonary machine), post-cross clamp and after prothamination. After the blood is divided into the centrifuge, the plasma is stored at -80 °C. The samples are measured by serum seruloplasmine, C-reactive protein (CRP), TAS, TOS and OSI colorimetric methods by solving in the autoanalytic device on the working day. Results: TAS value; pre-operative 0.95 ± 0.19, pump entry 0.73 ± 0.13, cross clamping after 0.84 ± 0.18, protamine after 0.92 ± 0.14 and p <0,001, TOS value respectively; 12.66 ± 3.21, 10.22 ± 3.28, 19.04 ± 6.00, 25.88 ± 8.14 and p <0,001, OSI; 1.35 ± 0.35, 1.48 ± 0.74, 2.38 ± 0.91, 2.81 ± 0.80 and p <0,001, Seruloplasmine; 1002,48 ± 209,20, 554.71 ± 125.77, 581.92 ± 156.67, 633.79 ± 166.69 and p01, CRP; 0.85 ± 1.44, 0.51 ± 1.09, 0.35 ± 0.47 ± 0.47 ± 0.29 ± 0.29 ± 0.29 ± 0.29 ± 0.29 ± 0. This study found a statistically significant difference between TAS, TOS, OSI and seruloplasmine levels (p<0,001). Serum CRP levels have not found a significant statistical difference between the groups.

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