Özet:

This manuscript has aimed to investigate the nephro-hepato protective potential and antioxidant role of lyophilized extract of hawthorn (Crataegus orientalis L) fruit (LEH) against carbon tetrachloride (CCl4) toxicity. The experimental were conducted as 0.5 ml/kg CCl4, bw), 100 mg/kg LEH bw, 200 mg/kg LEH bw, CCl4 0.5 ml/kg + 100 mg/kg LEH bw and CCl4 0.5 ml/kg + 200 mg/kg LEH bw treated with the extract for 3 weeks. At the end of the experimental treatment, the nephro-hepato protective potential and antioxidant capacity of the LEH was evaluated measuring by liver and kidney damage serum biomarkers, antioxidant defense systems constituents (ADSCs) and malondialdehyde (MDA) content in the erythrocyte, brain, kidney and liver tissues of rats. According to results liver damage serum enzymes activities and MDA content of the tissues were significantly higher in CCl4 group compared to normal control (NC) whereas these parameters were significantly lower in extract supplemented groups compared to CCl4 group. According to the resuls, the study results suggest that the LEH supplementations diet restored most of the parameters towards the NC values with fluctuations in the ADSCs. Therefore, it is thought that the extract of hawthorn has antioxidant capacity and hepatoprotective effects against in CCl4-intoxicated rats.

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