Abstract:

Background: The clinical manifestations of AKI are highly variable ranging from asymptomatic alterations in renal parameters to overt uremic symptoms. In rural population the common causes are tropical diseases, diarrhea, snakebite, poor obstetric care etc which are common among healthy young individuals. Many causes are potentially preventable with appropriate management. The present study was conducted in a tertiary care hospital from South India to find out the causes of AKI as there is limited data available, in particular with infectious diseases which are common in topical countries like India.Materials and Methods: This is an observational study done in patients admitted with AKI in wards and ICUs under the department of General Medicine during January 2019 to December 2019, in Maharajah’s Institute of Medical Sciences, Vizianagaram, Andhra Pradesh,India, a tertiary care hospitalResults: 144 patients who developed acute kidney injury, etiology and outcome of AKI was estimated. In our study, AKI is more common in males 86 out of 144 (59.7%) and most of them belong to age group between 30-59years (50%). Common causes of AKI in our study are infections of which urinary tract infection is most common contributing to 24.3%, followed by pneumonia (11.1%) and malaria (8.33%). The survival and death in relation to patients’ clinical presentation and baseline investigations except for blood urea was statistically significant.Conclusion: In our study population, infections were found to be the common cause for Acute Kidney Injury among which urinary tract infection was most common. There was no statistically significant difference in outcome (recovered, non recovered-CKD, death) in relation to etiology. There is statistically significant difference in outcome (mortality) with respect to clinical and laboratory profile at the time of admission.

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