Özet:

Purpose: There are a limited number of studies on the immune-regulating effect of natural killer cells (NK) in the bacterial disease (BD). In this study, active and inactive Behçet patients studied NKp30, NKp46, NKG2D, perforin and granzyme mRNA expressions. Method and method: The study included 42 Behchet patients and 14 healthy controls. NKp30, NKp46, NKG2D, perforin and granzyme mRNA expression levels were analyzed with RT-PCR, CD3+ T and NK cells flow cell measurements. Results: There is no significant difference between the patient and healthy tests in terms of NKp30, NKp46, NKG2D, perforin and granzyme mRNA expression levels. In active patients, a positive correlation was found between CD3-CD16+CD56dim NK cell rates and NKG2D and NKp46 mRNA expression levels, and in inactive patients, CD3+ T cell rates and NKp46 mRNA expressions. The result: Although there are no significant differences in terms of NKp30, NKp46, NKG2D, perforin and granzyme mRNA expressions, more functional work is required to exclude the potential role of these molecules in Behçet pathogenesis.

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