Özet:

Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia. The aim of this study is to evaluate the effects of melatonin on the skeletal muscle and heart muscle in DM rats. Tools and Methods: 36 men Wistar albino rat control group, control + melatonin group, diabetes group, diabetes + melatonin group divided into 4 groups. The treatment of melatonin (10 mg / kg, ip) was administered for four weeks. The levels of malondialdehitis (MDA) and reduced glutation levels (GSH) were evaluated with the levels of Nrf2 and thyroidoxin (TRX). Results: Diabetic group's skeletal and heart muscle MDA levels are high compared to control groups, while melatonin therapy has reduced this value significantly (p<0,05). The levels of GSH in the skeletal muscle were found high in the treatment melatonin diabetes group, compared to the diabetes group. In the diabetes group, the levels of the skeletal muscle Nrf2 have decreased according to the control groups. This decrease has increased its control values with the application of melatonin. Although the heart muscle Nrf2 levels are low in the diabetes group, this difference is not meaningful. There is no difference between the groups in the levels of the skeletal muscle TRX. The heart muscle TRX levels were low in the diabetic group while increased with melatonin therapy (p<0,05). The results of our study show that the oxidative stress formed by melatonin therapy by hyperglycemic can be reduced by the Nrf2 path in the skeletal muscle and by the TRX path in the heart muscle.

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