Abstract:

The aim of this study is to evaluate acute phase response and oxidative damage using the levels of haptoglobin (Hp), nitric oxide (NO) and malondialdehitis (MDA) in natural infected cows with Streptococcus pluranimalium. The study found that animal material was infected with S. pluranimalium between the ages of 4-6 and infected with 60 pieces (Infected group) and 15 healthy pieces (Control group) between the ages of 4-6 years. For microbiological analyses, blood samples were taken from the vein jugularies of animals for infected sheep's skin scratches and biochemical analyses. Examples from infected sheep were identified using S. pluranimalium, VITEK 2 Compact Bacterial Identification and Monitoring System. Serum Hp and NO levels were determined by a spectrophotometric method, while MDA levels were determined by the reaction of thyobarbituric acid (TBA). The levels of infected group Hp (0.17±0.01 g/L), (P<0.001) MDA (1.67±0.04 μmol/L) and NO (31.14±1.61 μmol/L) (P<0.01) were significantly higher than the control group. As a result, the high serum MDA and NO levels showed that oxidative damage occurred in natural infected cows with S. pluranimalium. However, it can be assumed that higher Hp and lower Alb concentrations may be an indicator of acute phase response in infected animals.

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