Abstract:

Aim: Subacute thyroiditis (SAT) is a thyroid disease that seriously affects the quality of life for patients caused by acute inflammation of the thyroid gland. Apart from classical acute phase reactants, the values and rates obtained from peripheral blood count (mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR)) values are also accepted as practical indicators of systemic inflammation. Our aim in this study is to compare the effects of systemic inflammation markers and the treatments given in the laboratory tests of our patients with a diagnosis of SAT, on the hypothyroid state one year later. Material and Methods: In this study, which was carried out with a retrospective method, 133 patients were included in the study. The medical data of these patients at the time of SAT diagnosis and one year later were analyzed. 37 patients were in the steroid group and 97 patients were in the nonsteroidal anti-inflammatory drug (NSAID) group. Results: The male/female ratio was similar in both groups. Female dominance was observed in both groups in patients diagnosed with SAT. The thyroid tests of the groups, which were hyperthyroid at the beginning and euthyroid one year later, were similar between the groups (p>0.05). Both groups had an increase in acute phase reactants at baseline (erythrocyte sedimentation rate [ESR] and C-reactive protein (CRP) levels) and normalized after treatment. Neutrophil (p<0.05), lymphocyte (p>0.05) and platelet (p<0.05) counts decreased with the reduction of inflammation. Monocyte count decreased in both groups, but it was significant in the steroid group, but not in the NSAID group. The development of permanent hypothyroidism was 8/37 (21.6%), 24/97 (24.74%) in steroid and NSAID groups respectively (p˃0.05). There was no statistical difference in inflammation markers (CRP etc.) and follow-up parameters before and after treatment in both groups (steroid vs. NSAID) with and without a diagnosis of permanent hypothyroidism (p>0.05). Conclusion: Inflammation markers and treatments applied in SAT patients did not have a significant effect on the prognosis