Kullanım Kılavuzu
Neden sadece 3 sonuç görüntüleyebiliyorum?
Sadece üye olan kurumların ağından bağlandığınız da tüm sonuçları görüntüleyebilirsiniz. Üye olmayan kurumlar için kurum yetkililerinin başvurması durumunda 1 aylık ücretsiz deneme sürümü açmaktayız.
Benim olmayan çok sonuç geliyor?
Birçok kaynakça da atıflar "Soyad, İ" olarak gösterildiği için özellikle Soyad ve isminin baş harfi aynı olan akademisyenlerin atıfları zaman zaman karışabilmektedir. Bu sorun tüm dünyadaki atıf dizinlerinin sıkça karşılaştığı bir sorundur.
Sadece ilgili makaleme yapılan atıfları nasıl görebilirim?
Makalenizin ismini arattıktan sonra detaylar kısmına bastığınız anda seçtiğiniz makaleye yapılan atıfları görebilirsiniz.
 Görüntüleme 12
Personalized Approaches To The Use Of Meldonium As A Cytoprotector In Patients With Coronary Heart Disease
2021
Dergi:  
Natural Volatiles and Essential Oils
Yazar:  
Özet:

Introduction: The personalized approach to prescribing medications to patients with stable angina pectoris has been designated as promising, “diamond”. How this is true for meldonium is to be sanctified in this article. Researchtasks: to develop a personalized approach to the use of meldonium in patients with coronary heart disease (CHD) based on the definition of criteria for predicting the cytoprotective properties of this drug when tested in vitro. Materialand Methods: We examined 30 patients with CHD: stable angina pectoris I-III functional classes with concomitant arterial hypertension. The patients underwent echocardiography, coronary angiography, biochemical blood test with determination of the cholesterol profile. To determine the cytoprotective activity of meldonium, blood leukocytes of patients were examined in vitro by fluorescence microscopy using an Eclipse Ti-U inverted fluorescence microscope (Nikon, Japan). By staining leukocytes with fluorescent dyes (Calcein AM, Ethidium bromide), living and dead cells were determined, and the cell viability index (VI cells) was calculated. The materials were processed statistically, the criteria for predicting the cytoprotective effect of meldonium were determined using Wald's prognostic analysis. Results: with the introduction of meldonium into a sample with a leukocyte suspension, two variants of changes in cell viability were observed: in 40% of patients, VI cells increased, on average, by 34% (from 28% to 62%, p <0.001) and in 60% of patients, VI cells decreased, on average , by 26% (from 52% to 26%, p <0.05). A number of conditions of the initial state of a patient with CHD were identified for the manifestation of the cytoprotective activity of meldonium: the initial stages of concomitant arterial hypertension (1-2), a pressure gradient on the pulmonary artery valve up to 3 mm Hg, the presence of violations of local myocardial contractility according to echocardiography, the presence of stenosis of coronary arteries (more than 60% in diagonal branch of the left coronary artery and more than 50% in the right coronary artery), normal (non-atherogenic) cholesterol profile with serum cholesterol levels less than 5.3 mmol / L and low density lipoproteins less than 2 mmol / L. Conclusion: the metabolic drug meldonium exhibits cytoprotective activity only in some patients with coronary heart disease (40%). At the same time, there are a number of conditions for the initial somatic status of the patient, which determine the advisability of using meldonium as a cytoprotector. 

Anahtar Kelimeler:

0
2021
Yazar:  
Atıf Yapanlar
Bilgi: Bu yayına herhangi bir atıf yapılmamıştır.
Benzer Makaleler












Natural Volatiles and Essential Oils

Alan :   Fen Bilimleri ve Matematik; Sağlık Bilimleri

Dergi Türü :   Uluslararası

Metrikler
Makale : 2.892
Atıf : 273
2023 Impact/Etki : 0.316
Natural Volatiles and Essential Oils