Özet:

Purpose: The purpose of this study is to determine the embryotoxic dose limit of detomidine by using the fertile chicken egg in-ovo model. In the study, 210 fertile eggs were divided into 7 equal (n: 30) groups and placed in the cutting machine in optimal conditions. The first group has not been implemented. On the seventh day of incubation, detomidine was administered in serum physiological doses of 10, 5, 2.5, 1.25 and 0.625 mg/kg, respectively. On the 21st day of the incubation, the eggs were opened and detected malformations, dead embryos and non-fertile eggs. Results: 0.625, 1.25 and 2. Detomidine in doses of 5, 5 and 10 mg/kg was identified in groups of 3, 2, 4, 6 and 5 dead embryos, respectively, while the dead embryos were not identified in the control and serum physiological groups. In the control and 5 mg/kg detomidine groups, one unfertile egg was identified, while in the other groups, no unfertile egg was observed. Death rates observed in the detomidine-admitted groups in doses of 2.5, 5 and 10 mg/kg were high in the control and serum physiological groups (p<0.05). Recommendation: Considering that the smallest dose used in this study is 7.8 times greater than the highest recommended dose for target species, normal doses of embryonic death may be considered safe in pregnant mammals. However, considering that the dose should be 100 times lower as a safety ratio for mammals, it should be taken into account that negative effects can also be observed.

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