Özet:

Purpose: First trimester screening tests are widely used today for the diagnosis of chromosomal anomalies. In our study we studied the impact of maternal smoking on the first trimester screening tests in pregnancies that apply to the laboratory. The first trimester pre-natal test results of a total of 900 females, including 700 smoking and 200 non-smoking, were scaned backward. The maternal serum PAPP-A, free ß- HCG, fetal CRL and NT values of all pregnancies were statistically evaluated. Results: Comparing the first trimester scan test parameters of the smoking and non-smoking group, only the PAPP-A value (p=0.023) found a significant difference. Age (p=0.088), PAPP-A MoM( p=0.981), free ß- HCG (p=0.668), free ß- HCG MoM (p=0. The values of 782, NT MoM (p=0.398) and CRL (p=0.210) did not make any significant difference between the two groups. Result: Smoking in pregnancies reduces the maternal serum PAPP-A level from the first trimester screening test parameters. Low serum PAPP-A levels are associated with other pregnancy complications, such as premature birth, pregnancy loss and low birth weight, in addition to chromosomal anomalies. As a result, we believe that a closer clinical monitoring of pregnancies with low serum PAPP-A levels may be helpful.

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