Özet:

Objective: There is growing resistance in most of the microorganisms causing urinary tract infections. The aim of the present study was to evaluate the prevalence of antibiotic susceptibility of ESBL-positive E.coli strains isolated from urine samples obtained from outpatient patients in the State Hospital. Material and Methods: Culture results retrospectively reviewed that E.coli isolated from mid-stream urine samples sent from various outpatient clinics with the suspicion of Urinary Tract Infections. The antibiotic susceptibility of the strains was determined using the Kirby-Bauer disc diffusion method in accordance with the principles of the Clinical and Laboratory Standards Institute (CLSI). ESBL production was studied by using the combined disc method according to CLSI standards. Results: The prevalence of ESBL-producing strains was found as 12.4%. The antibiotics to which ESBL producing strains are the most susceptible were as follows: imipenem, meropenem, nitrofurantoin. The antibiotics to which ESBL nonproducing strains are the most susceptible were as follows: imipenem, meropenem, piperacillin-tazobactam, cefoperazone-sulbactam, Sensitivity in terms of ESBL production, resistance rates were higher in ESBL producing E.coli than in nonproducing strains (p < 0.001). Conclusion: There is growing resistance in most of the microorganisms causing urinary tract infections. Every hospital should identify the antibiotic susceptibility profiles of its own prevailing strains, and their own antibiotic policies should be developed. It is important to maintain control over increasing antibiotic resistance and treatment success

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