Aim. The aim of our work was to develop the analytical support for pharmaceutical development for laboratory batches of solutions for peritoneal dialysis containing dextrose and sodium lactate. Methods. We used the following research methods: direct argentometric (determination of chloride ions), complexonometric (determination of the amount of calcium and magnesium ions), criometric (determination of osmolality and osmolarity), potentiometric methods, weighting, statistical methods and data processing of chemical experiments. Results. Firstly in Ukraine the results of standardization and the analytical support for pharmaceutical development for laboratory batches of solutions for peritoneal dialysis are presented in the article. Conclusions. Two procedures of quantitative determination of chloride-ions and complexonometric method of assay of the amount of calcium and magnesium ions are developed. These procedures are the basis for the quantitative determination of sodium chloride by calculation method and quantitative determination of magnesium ions by calculation method provided quantitative determination of calcium ions. The procedure of determination of the actual osmolality and osmolarity is established, acceptability criteria for osmolality and osmolarity for the solutions, which are investigated, are developed, the dependence between osmolality and osmolarity is established. The procedures of rapid quantitative determination of chlorides make it possible to assess the contribution of the stabilizer in total chloride content of solutions for peritoneal dialysis. Author Biographies Nataliia Hudz, Danylo Halytsky Lviv National Medical University Pekarska str., 69, Lviv, Ukraine, 79010 PhD, associate professor
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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