Amaç: İlk trimester lipid profilinin preeklampsi öngörüsünde faydasını ve yenidoğan sonuçlarıyla olan ilişkisini araştırmaktır. Gereç ve Yöntemler: Çalışmaya preeklampsi (PE) tanısı almış 121 hasta ve 99 sağlıklı gebe kadın dahil edildi. Çalışma retrospektif olarak dizayn edilmiştir. Hastaların yaş, gravida, parite, vücut kütle indeksi (VKI), doğum şekli, doğum kilosu, APGAR skoru, yenidoğan yoğun bakım ünitesi (YYBÜ) kabulü ve doğum haftası kaydedildi. Laboratuvar analizlerinde ilk trimester (<12 hafta) kolesterol, trigliserid, HDL, LDL düzeyleri tespit edildi. PE’li ve PE’siz iki grup oluşturularak karşılaştırma yapıldı. Her grubun lipid profili ile yenidoğan sonuçları arasındaki ilişki değerlendirildi. Bulgular: Gruplar arasında gravida ve parite sayıları arasında anlamlı fark yoktu. Yaş, VKI ölçümleri, doğum haftaları, doğum kiloları, YYBÜ kabulü değerleri arasında farklılık saptanmadı. PE grubundaki bebeklerin ortalama doğum haftaları, doğum kiloları ve APGAR skorları daha düşüktü. PE grubundaki bebeklerin sezaryan olma oranı daha yüksekti. Grupları arasında laboratuvar sonuçları incelendiğinde PE grubundaki tüm lipid ölçümleri anlamlı olarak daha düşüktür bulundu. Her iki grupta yenidoğan APGAR skoru ve YYBÜ ihtiyacı ile laboratuvar sonuçları arasında anlamlı bir ilişki saptanmadı (p<0.05). Sonuç: İlk trimesterde bakılan serum lipid profilindeki parametreler PE grubunda kontrol grubuna göre daha düşük bulundu. HDL düşüklüğü beklenen bir bulgu olmakla beraber kolesterol, trigliserid ve LDL düşüklüğü beklenti dışındadır. Sonuçlarımız serum lipid profilinin PE gelişmesini öngörmede yetersiz kalabileceğini düşündürmektedir.
Purpose: The first trimester is to explore the benefits of the lipid profile in the preeclampsia forecast and its relationship with the results of the newborn. The study included 121 patients diagnosed with preeclampsia (PE) and 99 healthy pregnant women. The work is retrospective. The patient’s age, pregnancy, parity, body mass index (VKI), birth form, birth weight, APGAR score, newborn intensive care unit (YBU) acceptance and birth week were recorded. Laboratory analyses identified levels of cholesterol, triglycerides, HDL, LDL in the first trimester (<12 weeks). It was compared by two groups with PE and without PE. The relationship between the lipid profile of each group and the result of the newborn was assessed. There was no significant difference between gravity and parity numbers between the groups. There is no difference between age, VKI measurements, birth weeks, birth pounds, YYBU accepted values. The average birth weeks of babies in the PE group, birth pounds and APGAR scores were lower. The number of babies in the PE group was higher. When the laboratory results were studied among their groups; all lipid measurements in the PE group were found significantly lower. There was no meaningful relationship between the newborn APGAR score and the YYBU need and the laboratory results in both groups (p<0.05). Result: Parameters in the serum lipid profile looked at in the first trimester were found lower than in the control group in the PE group. The low HDL is an expected outcome, but the low cholesterol, triglycerides and LDL are out of expectation. Our findings suggest that the serum lipid profile may remain insufficient in predicting PE development.
Aim: To investigate the benefit of first trimester lipid profile in predicting preeclampsia and its relationship with neonatal outcomes. Material and Methods: Plasma concentrations of cholesterol, triglyceride, HDL, LDL were meausred in 121 women with preeclampsia (PE) and in 99 healthy pregnant women in the first trimester (<12 weeks).There was a comparison between groups with and without PE. The relationship between lipid profile of each group and neonatal outcomes was evaluated. Results: There was no significant difference between the groups in gravida and parity numbers. Differences were found between age, body mass index (BMI) measurements, birth weeks, birth weights, and NICU acceptance values. Babies in the PE group had lower mean birth weeks, birth weight and APGAR scores. Babies in the PE group had a higher rate of cesarean delivery. When the laboratory results are examined among the groups; All lipid measurements in the PE group were found to be significantly lower. Conclusion: The serum lipid profile in the first trimester was found to be lower in the PE group compared to the control group. Although low HDL is an expected finding, the others are not expected. This suggests that the serum lipid profile may be insufficient to predict the development of PE.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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