Özet:

Chromium (Cr) is an essential trace element for insulin activity, connects to the insulin receptor, strengthens the effect of insulin in many functions, including the regulation of carbohydrate and lipid metabolism, and in all functions. The aim of this study is to investigate the effects of chromium histidine (CrHis) on the levels of three different isomeryins, pancreas glucose carrier protein 2 (GLUT-2), insulin receptor substrat (IRS-1) and glucagon-like peptide 1 receptor (GLP-1R) protein. In the study, 42 Sprague-Dawley races were randomly divided into six groups (n=7). The rats are grouped in the form of the isomer 1 (CrHis2) that is refined with YYD and CrHis; 4: the isomer 2 (CrHis2) that is refined with YYD and CrHis; 5: the isomer 3 (CrHis3) that is refined with CrHis; 6: the isomer 3 (CrHis3) that is refined with YYD and the isomer 3 (CrHisM) that is refined with the mixture of YYD and CrHis. Although the CrHis isomers were provided from different sources, the rats were given the same amount of Cr (10 μg elementary Cr/kg CA/day). The rats were fed with a high-fat diet to lower insulin resistance. The application of CrHis isomers improved the increased levels of pancreatic insulin with YYD. Insulin levels in the CrHis isomer groups were found significantly low compared to the YYD group (P<0.001). Pankreas GLUT-2, IRS-1 and GLP-1R protein levels were found significantly higher than the YYD group (P<0.001). Furthermore, the GLUT-2 and GLP-1R protein levels in CrHis1 group are higher than the CrHis3 group (P<0.001), while the difference between other isomers is not found (P>0.05). As a result, it is believed that against insulin resistance that may be formed with YYD, CrHis isomers or their mixture may have a protective effect against insulin resistance in the pancreas tissue.

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