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Doğal Olarak Kilo Alan veya Obezite Gelişen Kedilerde Lipid Profili, Oksidatif Stres ve Tiyol-Disülfür Düzeyleri Arasındaki İlişkiler
2024
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Bu çalışmada, doğal olarak fazla kilo almış olan veya obezitenin geliştiği kedilerde sistemik inflamasyonun, oksidatif stresin ve lipid profilinin değerlendirilmesi amaçlandı. Çalışmada, vücut kondisyon skoru (BCS) >8 olan on obez kedi (obezite geliştiren grup), BCS skoru >6 olan on fazla kilolu kedi (fazla kilolu grup) ve BCS skoru 4-5 olan on ideal kilolu kedi (kontrol grubu) incelendi. Aşırı kilo almış olan ve obezitenin geliştiği kedilerde, serum AST (P < ,001), albumin (P = ,002) ve toplam protein (TP) (P < ,001) düzeylerinin kontrol grubundaki kedilerde tanımlanan değerlerden anlamlı derecede yüksek olduğu belirlendi. Ayrıca, obezitenin geliştiği, kedilerde kan serumu yüksek yoğunluklu lipoprotein (HDL) (P = ,009) ve trigliserit (TG) (P < ,001) düzeyleri kontrol grubundaki kedilerde belirtilen değerlerden anlamlı derecede yüksek bulundu. Obezitenin geliştiği kedilerde, serum prokalsitonin (PCT), paraoksonaz-1 (PON-1), toplam tiyol, doğal tiyol ve MDA düzeylerinin aşırı kilolu kedilere göre anlamlı derecede yüksek olduğu saptandı (P < ,001). Sonuç olarak veteriner hekimlerin klinik değerlendirmelerinde, doğal olarak fazla kilo almış olan veya obezitenin geliştiği kedilerde, karaciğer fonksiyonları ve lipid metabolizması ile ilgili olan ve sistemik inflamasyon ve oksidatif stresi gösteren parametrelerdeki anlamlı düzeydeki değişiklikleri dikkate almalarının yararlı olacağı kanısına varıldı.

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The Relationship Between Lipid Profile, Oxidative Stress, and Thiol-Disulfide Levels in Healthy, Naturally Overweight and Obese Cats
2024
Author :  
Abstract :

This study aimed to evaluate systemic inflammation, oxidative stress and lipid profile in cats that had either naturally gained excess weight or had developed obesity. The following groups were examined in the study: ten obese cats with a body condition score of (BCS) >8 (the obesity group), ten overweight cats with a BCS score of >6 (the overweight group) and ten ideal weight cats with a BCS score of 4-5 (the control group). In the cats that had either gained too much weight or had become obese, the serum AST (P < .001), albumin (P = .002) and total protein (TP) (P < .001) levels were found to be significantly higher than the values determined in the control group cats. Furthermore, blood serum high-density lipoprotein (HDL) (P = .009) and triglyceride (TG) (P < .001) levels in cats that had developed obesity were found to be significantly higher than the values defined in the control group cats. In the obese cats, serum procalcitonin (PCT), paraoxonase-1 (PON-1), total thiol, native thiol and MDA levels were found to be significantly higher than in overweight cats (P < .001). As a result, it was concluded that it would be useful for veterinarians to consider significant changes in parameters related to liver function and lipid metabolism, as well as to emphasize systemic inflammation and oxidative stress in their clinical evaluations in cats that had either naturally gained excess weight or had developed obesity.

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