Abstract:

Purpose: In this study, melatonin studied the oxidative stress parameters in the liver tissue in experimental hypercholesterolemia, the effects of dimethylargin, which plays a role in nitric oxide metabolism, on the expression levels of dimethylaminohydrolase (DDAH) and histopathological changes. The rats were divided into 4 groups: a) control, b) hypercholesterolemia (HCT), c) melatonin (HCT-MEL, preventive), d) melatonin (HCT-2MEL, therapeutic) groups that were fed with the cholesterol diet and used only in the last 2 weeks. The findings: Despite an increase in MDA levels with hypercholesterolemia, DDAH protein expression and GSH levels have been seen to decrease. MDA levels, GSH activity and DDAH expression were normalized by melatonin applications. There have been significant changes in the liver tissue with hypercholesterolemia, such as sinusoidal conjection, foolish swelling, periportal cell infiltration, periasiner fertilization and apoptosis. The intensity of oil in the periportal and midzoneal areas in the HCT-MEL group decreased according to the HCT group. Compared to the two treatment groups, the histopathological preventive melatonin was more effective than therapeutic use. The result: Melatonin may be a hepatoprotective and/or therapeutic agent with an antioxidant effect on diet-induced hypercholesterolemia and may be a regulator of nitric oxide metabolism in preventing histopathological changes in liver pathogenesis.

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