Abstract:

The embryos implantation process in humans involves complex physiological mechanisms and is an important stage after fertilization to a healthy pregnancy. In humans, 6-10 days after fertilization, and in rats used as a model organism due to similar cycles to humans, 4.5-6.5 days cover the process called "implantation window". In the studies of the mechanisms that cause infertility, the implantation process plays an important role. This study aimed at creating resources for new studies with histological assessments related to the rats' implantation period and the collection of the latest literary information obtained. The female rats identified in the vaginal spread and esthrus stage, after fertilization, were divided into 3 groups, 4.5, 5.5 and 6.5 days of embryonic development, and the groups were obtained from the female rats identified (n:21) uterus samples. The tissues were detected in 10% formality, and were buried in the paraffin with routine paraffin tissue tracking. 5 mcgIt was painted with Hematoxylene-Eozin by taking paraffin cuts and periodic acid was assessed by Shiff reaction. Basic structures in the uterus were evaluated during the implantation process in painted cuts. The core structures seen in the process of implantation in the cuts are endometrium, myometrium, perimetrium, surface epithelium, primary and secondary desidual areas, GMB cells, trofoblast and embryoblast cells. The results are compared throughout the stages of the implantation period. The implantation process, which is one of the important stages for achieving a healthy pregnancy, is evaluated by stages in rats commonly used as a model organism.