Özet:

Background: Pseudo-Bartter’s syndrome (PBS) is a clinical entity characterized by hypokalemia, hypochloremia associated with metabolic alkalosis. It is different from Bartter’s syndrome, in which hypokalemic metabolic alkalosis may develop without primary renal disease. Cystic fibrosis (CF), pyloric stenosis, continuous gastric drainage, cyclic vomiting, chloride loosing diarhea, and inappropriate laxative use can cause PBS. PBS can be an initial manifestation of CF or develops during follow-up of CF. Aim: In this study, we aimed to evaluate patients with CF with respect to the development of PBS during diagnosis and follow-up period.Methods: Patients with CF who were following up in our pediatric pulmonology and gastroenterology departments were evaluated with respect to PBS diagnosed at the beginning or during the course of the disease. Patients’ demographic characteristics, duration of hospitalization, and biochemical values were presented. Results: PBS was diagnosed in 7 (41.2%) of the total 17 patients with CF. Four were girls (57.1%) and the mean age was 3.1±1.3 months (1-5 months). While, 5 (29.4%) out of 7 patients were diagnosed as PBS at diagnosis of CF, 2 (11.7%) developed PBS during follow up. Conclusion: PBS as the initial manifestation of CF has been reported in 6.4-16.8% of patients with CF. PBS has been detected in 41.2% in our patients, and PBS has been the initial manifestation in 29.4% of our patients. In conclusion, PBS is not a rare clinical picture and it should be considered in the evaluation of patients with CF

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