Özet:

Aim: Chronic myeloid leukemia (CML) is a myeloproliferative disease characterized by the presence of the bcr-abl fusion gene. Oxidative stress may play a role in the pathogenesis of this disease by causing DNA damage. Thiol molecules protect the organism from the harmful effects of oxidative stress. In this study, we aimed to investigate the thiol/disulfide balance in CML patients. Method: A total of 48 patients with CML and 80 healthy individuals were included in the study. The collected venous blood samples were centrifuged and the serum part was stored at -80 0C until all samples were studied. Native thiol, total thiol, disulfide and ischemia modified albumin (IMA) levels were studied from these blood samples. Results: The median Sokal score of the patients was calculated as 0.78 (0.56-1.37). In the Sokal score categories, a significant difference was found between the levels of native thiol, total thiol, disulfide/native thiol, disulfide/total thiol, native thiol/total thiol and IMA. When the patient and control groups were compared in terms of oxidative stress measurement, the measurements in the patients were found to be consistent with increased oxidative stress. Serum IMA levels were found to be significantly higher in patients in the high-risk group according to the Sokal score, and it was observed that IMA levels increased as the risk increased (p<0.001). Conclusion: Oxidative stress parameters are significantly higher in CML patients than in normal individuals. In particular, serum IMA levels are significantly higher in high-risk patients according to Sokal and can be included in future prognostic scores.

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