Özet:

Background: An e-cigarette is a cigarette that does not contain tobacco. The most toxic compounds in conventional cigarette smoke and e-cigarette vapors are carbonyls, such as formaldehyde which induce lung tissue damage. This study aims to compare the effect of exposure and the difference in duration of exposure to conventional cigarettes and electronic cigarettes on blood formaldehyde levels and alveoli histopathological features in Sprague dawley rats. Method: This research is an experimental study with 30 white Sprague dawley rats, male, aged 10-12 weeks, and with body weights of 150-250 grams. Rats will be necropsied after intervention for two weeks and four weeks. Blood samples will be examined for formaldehyde levels, and lung tissue will be assessed for alveolar damage. The results were analyzed by one-way ANOVA statistical for blood formaldehyde levels and Mann Whitney for the degree of histopathological damage to the alveoli. Result: There was no significant difference in blood formaldehyde levels between groups (p>0.05). There was an increasing trend in the intervention group compared to the control and in the fourth-week group compared to the second-week group. There was a significant difference in the degree of alveolar damage in the intervention group compared to the control (p<0.05). There was no significant difference between exposure for 2 and 4 weeks (p>0.05). Between rats given conventional cigarettes and e-cigarettes, there was no significant difference in the degree of alveolar damage at weeks 2 and 4 (p>0.05) Conclusion: Exposure to conventional cigarette smoke or electronic cigarette vapor has a significant effect on alveoli histopathological features

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