Abstract:

Propolis and royal jelly have been utilized in both traditional and modern medical practices since earlier times, owing to their diverse range of biological properties. Recent research has demonstrated their potential application in the realm of skin treatment and care. The purpose of this study is to examine the potential application of propolis and royal jelly in cream formulation and to evaluate the impact of the utilized bee products on the cream's anti-hyaluronidase, antioxidant, and antimicrobial activities. It is also investigate the physical stability of creams at various storage temperatures and durations. The cream formulation maintained ratio of royal jelly at 0.5%, while varying amounts of propolis extract ranging from 0.5% to 1.0% to 1.5% were utilized. The pH values of the creams examined in the study ranged from 5.56 to 6.02, indicating that they were compatible with the pH value of the skin. It was observed that the antioxidant activity values increased statistically as the propolis ratio increased in the cream formulation. As a result of the antihyaluronidase activity analysis of the cream samples, the IC50 values were determined as 0.16672-3.34603 g/ml cream and the Cream 3 sample with 1.5% propolis extract showed the highest activity. The cream samples with propolis and royal jelly exhibited inhibitory activity against Bacillus cereus, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans. The results of accelerated stability testing indicate that the cream formulation exhibits exceptional stability when subjected to various stress situations. This research provides evidence of the feasibility of integrating bee products into cream formulations to enrich them with natural, sustainable and safe skin care products in the cosmetics industry.

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