Abstract:

Objective: It has been demonstrated that increased oxidative stress and inflammation are associated with increased cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD) and proteinuria. In recent years, it has been understood that vitamin D (VD) has many roles, with the demonstration of the VD receptor in many tissues. In this study, we aimed to evaluate the association of VD level with inflammatory parameters and proteinuria in individuals with CKD. Method: The study included 314 patients who were followed up in the nephrology outpatient clinic with the diagnosis of CKD, had not received renal replacement therapy yet and met the inclusion criteria. The data of the participants were analyzed retrospectively and cross-sectionally. Demographic characteristics, creatinine, estimated glomerular filtration rate, serum 25(OH)D3, calcium, albumin, phosphorus, parathormone (PTH), spot urine protein/creatinine ratio, neutrophil, lymphocyte, platelet, neutrophil/lymphocyte ratio (NLR) and platelet /lymphocyte ratio (PLR) were recorded. According to serum 25(OH)D3 level; Three groups were formed those with VD deficiency (<10 ng/ml), those with VD insufficiency (10-29 ng/ml), and those with normal VD level (>29 ng/ml). The groups were compared in terms of inflammatory parameters and proteinuria levels. Analyzes were performed by using the SPSS 23.0 program. Results: There was no difference between the VD groups in terms of inflammatory parameters (CRP, NLR, and PLR). The protein/creatinine ratio in spot urine was higher in patients with VD deficiency than both those with VD insufficiency (p:0.007) and those with normal VD levels (p:0.001). In addition, a negative correlation was found between VD level and proteinuria (r: -267, p: <0.01). It was found that the association between VD level and proteinuria was preserved in individuals with proteinuria below the nephrotic level (p: 0.018). Conclusion: It was observed that the proteinuria level was negatively correlated with the VD level and reached higher values in those with VD deficiency. At this point, the role of VD in reducing proteinuria, which is an important factor in renal and cardiovascular terms, may become a current issue.

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