Abstract:

Objective: Interstitial cystitis (IC), also known as bladder pain syndrome (BPS), is a type of chronic suprapubic pain that symptoms include feeling the need to urinate right away and needing to urinate often. Dekspanthenol, a derivative of pantothenic acid (vitamin B5) is decreased the oxidative stress and inflammation besides that has been indicated posivitive effect of healing wound. In our study, we aim to compare the effects of Dekspanthenol on inflammation and oxidative stress in the bladder to chondroitin sulfate and hyaluronic acid which used routinely intravesical agents treatment of IC. Materials and Methods: Forty Wistar Albino rats were used as a sample and divided five groups which were determined control, chemical cystitis (CC), CC+Dekspanthenol, CC+chondroitin sulfate and CC+hyaluronic acid groups. The chemical cystitis model was obtained with an intravesical instillation of hydrochloric acid (0.2 mL of 0.4 NHCl) and in control group rats were applied the only 0.9% NaCl. The CC+Dekspanthenol group were treated with 2 mL 0.9% NaCl solution containing 500 mg/kg Dekspanthenol. The CC+chondroitin sulfate group were treated with 2 mL chondroitin sulfate (0.2%) and the CC+hyaluronic acid group were treated with 2 ml hyaluronic acid (0.5%). These agents were applied for that three treatment group twice a week for four weeks. Additionally, the 0.9% NaCl installation was performed for the same period to achieve similar stress in CC and control groups. All rats were performed to cystectomy with an abdominal incision and blood sample were taken from their hearts one day after the end of the treatments. Histopathological assessments were done on bladder tissue and malondialdehid (MDA), Superoxide Dismutase (SOD) and prolidase values were defined in blood samples. Results: It was detected that the leukocyte count of the group treating with Dekspanthenol decreased compared to the cystitis group in the histopathological examination of the tissues (p<0.05). However, this improvement was less than the other treatment groups. There was a significant difference between the tissue MDA values of the control and cystitis groups, but there was no difference between serum MDA, serum prolidase, and serum and tissue SOD values. The serum and tissue MDA and serum prolidase values decreased and serum and tissue SOD values increased in all three treatment groups compared to the cystitis group (p>0.05) and with this improvement in MDA, SOD and prolidase values of the treatment groups, it was observed that they approached the levels in the control group without cystitis. Conclusions: The Dekspanthenol treatment reduces oxidative stress, increases anti-oxidative effect and suppresses inflammation at tissue level in the interstitial cystitis model. We believe that Dekspanthenol will be used alone or in combination therapy in interstitial cystitis in the future, because of that it effects were similar like the current agents used in the clinic and cost-effective.

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