Özet:

Purpose: The purpose of this study is to evaluate the effect of Chlorogenic Acid (CGA) on tissue damage associated with ischemic reperfusion in the muscle tissue of the rats. Tools and Methods: Thirty-two Wistar Albino species female rats were supplied. These rats were randomly divided into four groups equally (n=8). The formed groups were identified as sham (S), ischemic-reperfusion (IR), 5 mg/kg Chlorogenic Acid (CGA5) and 10 mg/kg Chlorogenic Acid (CGA10) and undergoed surgery. The sham groups were opened from the back area to the right nefrectomy. The back area of the rats in other groups except Sham was opened and the left renal artery clamped after the right nefrectomy was performed. Chlorogenic acid was administered intraperitoneally in the form of two doses, 10 minutes before ischemic and 10 minutes before reperfusion. A 24-hour reperfusion was applied to the left kidney after 1 hour ischemic. After the procedures were completed, the total antioxidant levels (TAS), total oxidant levels (TOS), superoxid dismutaz (SOD), malondialdehitis (MDA) and myeloperoxidase (MPO) levels in the lungs tissues were measured by spectrophotometric methods. The oxidative stress index (OSI) is calculated. Results: In the IR group, compared to S, the TAS and SOD values declined, while the TOS, MDA and MPO values increased. In the CGA applied groups there was an increase in the TAS and SOD values, while in the TOS, MDA and MPO values there was a decline. The result: CGA treatment is believed to be effective in reducing oxidative stress damage developing in the lungs associated with renal ischemic reperfusion.

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