Özet:

The knowledge about coagulation disorders in patients with liver cirrhosis changed in the last decade. The conventional coagulation tests (the prothrombin time – PT, activated partial thromboplastin time – APTT) do not accurately reflect the complex modifications of the hemostasis in cirrhotic patients, as opposed to the thrombin generation test which can offer more precise information regarding the coagulation status. Thrombin generation could be a superior test compared to conventional coagulation tests in assessing the bleeding risk in cirrhotic patients. Patients with cirrhosis and relatively high levels of thrombin generation have a hypercoagulable state and this may pose a risk of thrombotic events, at the same time, patients with relatively low levels of thrombin generation, may present a hemorrhagic risk. The purpose of this study is to assessing the thrombosis and hemorrhagic risk in 41 patients with liver cirrhosis. The study of thrombin generation in patients with liver cirrhosis reveals that this test evaluates more accurately the risk of hemorrhage and thrombosis compared to the conventional tests, because it takes into account both the pro- and the anticoagulation factors.

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