Abstract:

Aim: Still there is no any specific laboratory marker for diagnosis of FMS and it mainly depends on clinical examination. So that we aimed to evaluate whether serum Vitamin C levels and oxidative stress index (OSI) can be used in the diagnosis of Fibromyalgia Syndrome (FMS). Material and Method: 53 female patients and 35 healthy female controls were enrolled to our cross-sectional study. VAS, BDI and FIQ were applied to the patients. Vitamin C levels were measured by HPLC. Total Antioxidant Capacity (TAC) and Total Oxidant Status (TOS) levels were determined by Spectrophotometric Assay method. Results: While vitamin C and TAC levels of FMS patients were significantly lower than those of the controls, OSI was significantly higher in patients (p= 0.004, p= 0.009 and p= 0.048, respectively). There was a moderate positive and significant relationship between the tender points and FIQ, (r = 0.505; p <0.001). The diagnostic performance of Vitamin C and TAC with ROC analysis were found: AUC = 0.678, p= 0.003, AUC = 0.639, p= 0.028 respectively. Conclusion: Serum TAC and vitamin C levels decrease and OSI increases in FMS patients. It can be suggested that these three parameters can be considered as an additional tool for diagnosis of FMS.

Keywords: