Özet:

Purpose: in polysithemia vera (PV) JAK2 V617F mutation is detected at 95% of the rate. But this test is both expensive and time-consuming. In this study, a quick, cheap and easy-to-access investigation is planned to be used as an additional to the JAK2 V617F mutation to eliminate secondary polysithema (SP). Patients and Method: This study included 39 PV patients and 51 SP patients diagnosed according to the World Health Organization’s 2016 diagnostic criteria. The demographic characteristics of the patients, the findings of the physical examination and the laboratory results were identified. A statistical analysis was made between the two groups. In the PV group, the serum B12 level, the number of erythrosites, the number of leukocytes, the number of neutrophils, the number of thrombocytes and the laktate dehydrogenase levels were statically significantly higher than the SP group. The serum B12 level is above 343 pg/mL and is determined as a margin for the PV-SP distinction. The result: High serum B12 levels have been found associated with PV. But to be used in the primary and secondary polysithemia specific diagnosis of serum B12 levels, this study requires prospective studies with a wider series of patients supporting the data.