Özet:

Purpose: Resveratrol was first isolated from the roots of the plant in the family of Melanthiaceae (Docutepegiller) in 1940. In the plants, it is high in concentration in red grapes, soil, ananas, dust and wild mercury. Resveratrol (3,5,4'-trihydroxistilben) is a natural polyphenol with various biochemical effects, as well as anti-inflammatory, anti-bacterial, anti-inflammatory, anti-proliferative effects. Antimicrobial and antifungal is an effective compound, namely phytoaleksin, produced by plants against microbial, fungal and physical stimulants. This study has studied whether resveratrol obtained from the root of Polygonum Cuspidatum has a reducing or stopping reproduction effect on some microbial and fungal human infections. Method: This study used Candida albicans, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus microorganisms. Each of the microorganisms used in the study was planted in their proper nutrients for their reproduction. Each microorganism is planted in its nutrients containing resveratrol in 1/4 and 1/1 dilution proportions and is left in incubation for certain periods for the reproduction of the organisms. The findings: At the end of this period, the beta hemolysis and reproduction of Staphylococcus aureus in his non-resveratrol diet was detected, while the ability to make beta hemolysis in the 5% sheep blood diet containing 1/1 and 1/4 dilution resveratrol was lost, and the reproduction in the 1/1 and 1/4 dilution resveratrol in Mueller Hinton diet was inhibited. In foods that do not contain and contain resveratrol (1/1 and 1/4 dilution) there is no change in the reproduction of Escherichia coli, Pseudomonas aeruginosa and Candida albicans microorganisms. The result: In addition to the effects of resveratrol on gram-positive bacteria, the therapeutic and protective effectiveness of resveratrol can be evaluated by new studies, combined with various antibiotics and disinfectants.

Anahtar Kelimeler:

Özet:

Aim: Resveratrol was first isolated from the roots of the plant in the Melanthiaceae family in 1940 and is found in plants at high concentration especially in red grapes, peanuts, pineapples, berries, and blueberries. It has antioxidant, antifungal, antibacterial, anti-inflammatory, anti-proliferative effects as well as is a natural polyphenol with various biochemical effects. In this study, it has been investigated whether resveratrol obtained from Polygonum Cuspidatum root has a reducing or inhibitory effect on some microbial and fungal human infections. Method: In this study; Candida albicans, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus microorganisms were used. Each of the microorganisms used in this study was implanted on suitable media for their reproduction. Each microorganism was implanted in normal media without resveratrol as well as in medias containing resveratrol at 1/4 and 1/1 dilution rates and incubated at a specific period for the growth of organisms. Findings: At the end of the incubation period, beta hemolysis and reproduction of Staphylococcus aureus were detected in the resveratrol-free medium. Ability to make beta hemolysis in 5% sheep blood medium containing resveratrol with 1/1 and 1/4 dilution was lost and its growth was inhibited in Mueller Hinton medium containing resveratrol with 1/1 and 1/4 dilution. No change was observed in the growth of Escherichia coli, Pseudomonas aeruginosa and Candida albicans microorganisms in the media with (1/1 and 1/4 dilution) and without resveratrol. Conclusion: In addition to the effects of resveratrol on gram-positive bacteria, its therapeutic and protective efficacy in combination with various antibiotics and disinfectants can be evaluated with new studies.