Abstract:

Purpose: Information on systemic inflammatory indices in the field of neonatology is limited. How sex and mode of delivery affects systemic inflammatory indices is unknown. The aim of our study was to evaluate the effect of mode of delivery and sex on systemic inflammatory indices in preterm infants. Materials and Methods: Preterm infants <32 weeks of gestation were evaluated retrospectively. Complete blood count parameters, monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), pan immune inflammation value (PIV), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), systemic inflammation response index (SIRI), demographic and clinical characteristics were compared in terms of sex and mode of delivery. Results: In our study, 1322 preterm infants were evaluated. Leukocyte, platelet, neutrophil, monocyte, lymphocyte count, hemoglobin levels, NLR, MLR, PLR, PIV, SII, and SIRI values were found to be similar between genders. Leukocyte, neutrophil, monocyte, lymphocyte count, hemoglobin levels, MLR, PLR, and SIRI values did not differ significantly according to mode of delivery. The values of platelet count (225 103 µ/L), NLR (0.30), PIV (42.17) and SII (67.86) in the cesarean section group were higher than those in the vaginal delivery group (platelet count: 248 103 µ/L, NLR: 0.44, PIV: 80.88 and SII: 91.63). Conclusion: Gender had no effect on systemic inflammatory indices and NLR, PIV, and SII were lower in cesarean delivery in preterm infants born <32 weeks of gestation.

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