Özet:

Purpose: Respiratory distraction syndrome (RDS) is the main cause of morbidity and mortality in premature babies. While the important factor in the development of RDS is gestational age, some maternal and fetal factors are also effective in the development of the disease. Steroids are known to stimulate output production and output secretion during the birth act by means of c-AMP (small adenosine monophosphate). Some premature babies do not develop RDS. It suggests that postnatal course of this disease is likely to be associated with the baby’s endogenous response to stress. In this study, RDS developed babies studied endogenous cortisol responses to stress. 20 babies with respiratory distraction syndrome, 19 babies with light respiratory distraction and 25 healthy babies with gestational age ranging from 28 to 35 weeks, postnatal 2-8 hours and 2 day cortisol levels were studied.  Results: The average level of 1.cortisol in the RDS group (52.90±57.47 μg/dl) was higher than the control group (29.51±13.52 μg/dl) and these findings were statistically meaningful (P<0.05). Similarly, the average cortizol levels in the light RDS group were significantly higher than the control group (P<0.05) (71.61± 81.97 μg/dl). Postnatal 2 days cortizol levels increase due to increased stress in RDS babies (71.14 ± 79.04 μg/dl) in control groups and slight respiratory distraction babies (respectively, 22.09 ± 11.29 and 45.12 ± 41). The results: These findings show that the endogenous cortisol response to stress in premature babies is quite good, and RDS is not directly related to the cortisol response. Keywords: endogenous response, cortisol, respiratory distress syndrome