Özet:

The SARS-CoV-2 caused by COVID-19 has a high rate of infection and the potential to cause severe diseases, which has been defined by the World Health Organization as a global pandemic. Many drug studies are being conducted to prevent COVID-19 pandemic today, but there is no effective and safe drug for treatment yet. These researches are scaned with many computing-backed drug design methods against the proteins that are effective in the replication and transcription mechanism of SARS-CoV-2 to pass to clinical stages quickly and at low cost. Through this, the effectiveness of experimental studies is illuminated at a molecular level the effectiveness of compounds tested towards the important structural proteins of SARS-CoV-2. In this study, previously experimental studies have determined the effectiveness of 32 calcon derived compounds with the molecular coating method of the SARS-CoV-2 Main protease (Mpro) enzyme in silicone biological effectiveness and molecular mechanism. According to the results of this study, the compounds showed a better link affinity to SARS-CoV-2 Mpro compared to the reference compounds (N3) of the target proteins 5, 6, 14, 25 and 32. As a result of these data, high biological effectiveness for the treatment of COVID-19 disease has been determined by chemical compounds. This information will guide clinical trials to develop more effective antiviral drugs for the treatment of COVID-19.

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