Özet:

Aim: Due to the widespread use of broad-spectrum antibiotics in recent years, the increase in multidrug resistant bacteria has become an urgent problem worldwide. In this study, it was aimed to determine the antimicrobial resistance patterns of Gram negative bacteria isolated from blood culture samples and to contribute to empirical treatment and antibiotic use policies. Material and Methods: 495 Gram negative bacteria isolates isolated from blood cultures sent to our laboratory between June 2018 and June 2021 were retrospectively analyzed. Traditional methods and a fully automated device (VITEK2, bioMerieux, France) were used for the identification of bacteria. After typing, antibiotic susceptibility tests of microorganisms were performed with the VITEK2 system, interpreted according to EUCAST (European Committee on Antimicrobial Susceptibility Testing) criteria. Results: Gram-negative isolates were frequently isolated from intensive care units (39%). In order of frequency, the agents detected in Gram-negative bacteremias were; Escherichia coli 33.9%, Klebsiella pneumoniae 19.1%, Acinetobacter spp. 18.5%, Pseudomonas spp. 10.3% and, Enterobacter spp. 4.6%. Less resistance was found in E.coli against carbapenems (meropenem 0%, imipenem 2.9% and ertapenem 3.7%), tigecycline 1.8%, and amikacin 2%. Less resistance rates in Enterobacterales isolated were found against carbapenems (6.8-14.5%), amikacin (10.6%) and tigecycline (15.9%),respectively. Less resistance was detected against amikacin (11.8%) and carbapenems (13.7-22.7%) in Pseudomonas spp. Conclusion: The high rates of resistance to some antibiotics other than carbapenems, amikacin and tigecycline indicate that empirical antibiotic therapy should be applied carefully to the patients. We are of the opinion that these results will contribute to the rational use of antibiotics and the choice of empirical treatment in our hospital.

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