Abstract:

In this study, we aimed at determining the levels of ischemic modified albumin (IMA) and the Karotis intima media thickness (KIMK) in patients with Primer Sjögren syndrome (PSS) and the relationship between the levels of IMA and inflammatory parameters and atherosclerosis. The study included 20 patients with PSS and 20 healthy tests. In clinical and laboratory assessments, erythrosite sedimentation speed (ESH), C-reactive protein (CRP), visual analog scale (VAS)- oral and VAS- eye dryness parameters were used. Everyone who participated in the work was a woman. The average age of participants was 46.6±9.1 years. The average age of Primary SS patients was 47.1±7.7 years and the average age of the control group was 46.1±10 years. The average duration of the disease in Primary SS patients was 5.8±4.4 years. There was no statistically meaningful difference when compared the IMA values between the patient and the control groups (Responsably 506.4±52.8 AbsU vs. 482.7±34.7 AbsU; p=0.101) and no statistically meaningful correlation when the relationship between the clinical parameters was studied. The carotis intima media thickness was statistically significantly high in the patient group compared to the control group (respectively 0.70±0.13 mm vs. 0.61±0.09 mm; p= 0.016). When the relationship between the karotis intima media thickness and clinical parameters was studied, a statistically meaningful correlation between KIMK and age (r=0.700, p<0.001) and ESH (r=0.312, p=0.05) was found. As a result, our study has shown that the IMA values are normal and the KIMK values are high and there is no relationship between the two. The high thickness of Karotis intima media may be a message of cardiovascular disease in patients with PSS who do not have cardiovascular risk factors. More clinical studies are needed to evaluate the IMA levels in Primary SS patients.