Özet:

Purpose: Zinc plays an important regulator in erythroid cell growth by modulating the specific gene expression to the erythroid series, providing normal erythroposis by taking a potential role in the serial development of hematopoietic root cells and megacaryosites. The lack of zinc has been to cause anemia by affecting the biosynthesis of hemoglobin. The aim of this study is to evaluate the relationship between serum zinc levels and hematological parameters of hemodial patients. Individuals and Method: In a special dialytic center, which varies between the ages of 19-65 years, 36 men and 29 women who entered the dialytic three days a week received a total of 65 adult volunteer patients. The patient’s face-to-face contact method and general information, the survey form containing health information were applied and the patient’s biochemical parameters of the last three months were recorded by taking from the files. Patients were taken three-day food consumption records, including a day of dialytic-one day of non-dialytic and a weekend. 10 ml blood samples from patients after at least 8 hours of hunger for serum zinc analysis were taken by the hemodialist. Serum Zinc Analysis was performed on the Perkin Elmer brand device with the ICP-MS (Inductively Coupled Plasma Mass Spectrometry) technique at the Selçuk University Advanced Technology Application Laboratory. Results: Serum zinc levels in the average and percentage range (IQR) values are 106.7 and 46.9 μg/dL in men and 110.2 and 48 in women respectively. It was found at 6 μg/dL (p>0.05). The patient’s serum zinc levels and hemoglobin (r=0.344, p=0.005), hematokrit (r=0.336, p=0.006), total iron connectivity (r=0.302, p=0.014) levels have been found in a positive direction. There is no relationship between serum zinc levels and serum iron levels (r=0.072, p=0.567) and serum ferritin levels (r=0.073, p=0.552). There was no connection between the patient’s serum zinc levels and diet and iron intake (r=0.030, p=0.810). The result: The correlation between serum zinc levels and some hematological parameters in hemodialysis patients suggests that serum zinc levels may be associated with anemia that is frequently observed in these patients.

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