Abstract:

A parameter used in determining the glomerular filtration rate (GFR) that indicates the renal functions of systatine C is known to be increased in obesity. In this study, our goal is to investigate the effect of sistatine C in the calculation of GFR in obese individuals infected with HIV. Methods and Requirements: Infectious Diseases of HIV-infected patients who are obese were included in the study. After measuring the lengths with naked feet and back on the wall on a flat floor of individuals, in the bioimpedans device (Tip-BC-418-MAIII, Tanita Body Composition Analyzer; Tanita, Tokyo, Japan) the entire body analysis was performed and the weight, body mass index (BMI), fat percentage, fat weight and non-fat weight were detected. The biochemical data has been evaluated retrospectively. Patients with Cystatin C, creatin values were calculated with CKD-EPI GFR (Chronic Kidney Disease Epidemiology Collaboration equation glomeular filtration rate), GFR cr (creatin-GFR), GFR cys (systatin-GFR) and GFR cre-cys (combined-GFR). In individuals infected with HIV (n=5), with an excessive fat percentage of over 9.21%, the Cystatin was found to increase with a high correlation in proportion to body weight and total cholesterol, while the GFR cre, GFR cys, GFR cre-cys were found to decrease in proportion to the increase. In individuals infected with HIV (n=29) with a fat surplus of less than 9.21%, Cystatin was found to be reduced in proportion to GFRcys. PROPOSITION and RESULTATION: The increased correlation between body weight and Cystatin in individuals with HIV infection and high fat tissue has shown that inflammation caused by HIV infection and excess fat tissue may have contributed to the rise of Cystatin. It has come to the conclusion that it needs to work more in the wider series on this.

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