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Amaç: Capparis spinosa (C. Spinosa) antioksidan, antienflamatuar, antialerjik, antiviral ve antikanserojenik özelliği gösteren flavanoit molekülü içerir. Bu çalışmanın amacı sıçanlarda palatinal bölgede oluşturulan yara modelinde C. spinosanın yara iyileşmesi üzerindeki etkisinin değerlendirilmesidir. Yöntem: Çalışmada 60 adet erkek Wistar sıçan kullanıldı. Başlangıçta iyileşme referansı olarak (0 gün) altı hayvan sakrifiye edildi. Sıçanlar C. spinosa, Klorheksidin (Klx) ve Kontrol (K) grubu olarak üç gruba ayrıldı. Tüm gruptaki denekler rastgele seçilerek altışar sıçandan oluşan dokuz alt grup oluşturuldu. Anestezi altına sıçanların damaklarının tam ortasında punch ile 3 mm çapında sirküler eksizyonel yara yüzeyleri oluşturuldu. Mukoperiosteal kısım keskin diseksiyonla uzaklaştırıldı ve açık kemik yüzeyindeki alan sekonder iyileşmeye bırakıldı. C. Spinosa, 1 ml/gün olacak şeklide gavaj yoluyla lokal olarak uygulandı. Sıçanlar yedinci, 14. ve 21. günlerde sakrifiye edildi ve yara bölgesinin fotoğrafları çekildi. Her bir fotoğraf özel bir programa aktarılarak defekt bölgesindeki yara alanı ölçüldü. Histolojik kesitler alınarak enflamatuar hücre varlığı, epitelizasyon ve iyileşme düzeylerine bakıldı. Bulgular: Epitelyal marjinler arasındaki ortalama yara alanı, tüm gruplarda zamanla önemli ölçüde azaldı (p <0.05). C. Spinosa grubu, Klx ve K grubu ile karşılaştırıldığında yedi, 14 ve 21. günlerde (sırasıyla 6.43±0.65 3.87±0.50 0.94±0.39) belirgin bir yara alanı azalması gözlemlenmiştir. 21. günde, kontrol grubunda hala enflamatuar hücreler gözlenmiştir. Sonuç: Çalışmanın bulguları ışığında C. Spinosa yara iyileşmesini hızlandırarak yumuşak dokunun iyileşmesinde olumlu etkileri gözlenmiştir.
Purpose: Capparis spinosa (C. Spinosa) contains an antioxidant, anti-inflammatory, anti-allergic, antiviral and anti-cancerogenic molecule. The aim of this study is to evaluate the impact of C. spinoza on the healing of the wound in the palatinal area in rats. Method: In the study, 60 male Wistar rats were used. Initially, six animals were sacrificed as a reference to healing (0 days). The rats were divided into three groups as C. spinosa, Chlorhexidine (Klx) and Control (K). The subgroups of all the group were randomly selected and formed nine subgroups consisting of the six-threatening horse. Circular excision wound surfaces with a diameter of 3 mm were created in the midst of the shells of the rats under anesthesia. The Mukoperiosteal part was removed with sharp disection and the area on the open bone surface was left to secondary healing. C. Spinosa was applied locally through the gage in the form of 1 ml/day. The rats were sacrificed in the seventh, 14th and 21st days and photographs of the wound area were taken. Each photo was transferred to a special program and the wound area in the defect area was measured. By taking histological cuts, the presence of inflammatory cells, epithelization and healing levels were considered. Results: The average wound area between the epithelial margins decreased significantly over time in all groups (p <0.05). C. Spinosa group, compared to Klx and K group, observed a significant decrease in the wound area in seven, 14 and 21 days (respectively 6.43±0.65; 3.87±0.50; 0.94±0.39) in comparison. 21 of 21. In the day, inflamatory cells are still observed in the control group. In light of the findings of the study, C. Spinosa has seen positive effects on the healing of soft tissue by accelerating the healing of the wound.
Aim: Capparis spinose (C. Spinosa) contains flavanoids and quercetin monoliths showing antioxidant, antiinflammatory, antiallergic, antiviral and anticarcinogenic properties. The aim of this study was to investigate wound healing effects of Capparis Spinosa on rat palatal mucosa. Methods: Sixty male Wistar rats were used to study. Six animals were sacrificed at baseline as baseline wound (0 day). The rats were divided into three groups as C. Spinosa, Chlorhexidine (Clx) and Control (C). Subjects in all three groups were randomly selected to form nine subgroups consisting of six rats. Under anesthesia, circular excisional wound surfaces of 3 mm in diameter were formed by punching in the middle of the rat’s palate. The mucoperiosteal part was removed with sharp dissection and the area on the open bone surface was left to heal the secondary. C. Spinosa was locally administered at a rate of 1 ml/day. The rats were sacrificed on days seven, 14 and 21 and pictures of the wound area were taken. Each photograph was transferred to a special programe to measure the defect area. Histologic sections were taken and the presence of inflammatory cells, epithelization and healing levels were evaluated. Results: The mean wound area between the epithelial margins decreased significantly with time in all groups (p < 0.05). A significant rate of wound area reduction was observed following the use of C. Spinosaat seven, 14 and 21 days (respectively 6.43±0.65; 3.87±0.50; 0.94±0.39)compared to Clx and Control. On day 21, the inflammatory cells were observed still in control group. Conclusion: The findings of the study showed that C. Spinosa had a positive effect on the healing of soft tissue by accelerating wound healing.
Alan : Sağlık Bilimleri
Dergi Türü : Ulusal
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