Özet:

The most common metabolic disorder in pregnancy is diabetes mellitus (DM). Gestational diabetes mellitus (GDM) is a glucose tolerance disorder that occurs for the first time during pregnancy or is diagnosed during pregnancy. Especially in the last period of pregnancy, the glucose metabolism is regulated in the form of providing the mother's energy needs from alternative sources (free fatty acids, ketons and glycerol) by directing rapidly growing fetus glucose and amino acids. Its basic function is known that irisine, which allows the energy to appear as heat by turning the white fat tissue into the brown fat tissue and is stimulated by exercise, has many physiological properties such as weight loss, insulin resistance reduction, obesity, glucose regulation and lipid metabolism. This study aims to study the levels of iris, a new hormone involved in energy metabolism in patients with GDM. Materials and Methods: The study included a total of 80 patients, including 40 pregnancies (Group 1) followed by the diagnosis of GDM at the Faculty of Medicine of the University of Fırat for Women's Diseases and Birth Clinic and 40 healthy pregnancies (Group 2) without any problems in pregnancy. These groups were divided into 20 patients in the second trimester with GDM (Group 1A), 20 patients in the third trimester with GDM (Group 1B) and 20 patients in the healthy second trimester (Group 2A) and 20 patients in the healthy third trimester (Group 2B). Results: Our study found a significant increase in serum iris levels in GDM groups (263,70±127,69 ng/ml), which were higher in the second trimester compared to the control groups. The need to question physical activity and exercise in future studies has been found that more comprehensive experimental and clinical studies are needed and that if the physiopathological mechanisms between GDM and iris can be illuminated, there may be clinically related therapeutic options for iris.

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