Özet:

Objective Thyroid cancer is the most common endocrine Malignancy, and nodules characterize its clinical presentation. 'Atypia of undetermined significance' (AUS) in biopsies performed for thyroid pathologies is an essential concern for clinicians due to different malignancy rates in the literature. In this study, we aimed to discuss the malignancy rates in patients who underwent thyroid surgery for AUS. Material and Method The demographic and histopathologic data of 174 patients diagnosed with AUS on fine needle aspiration biopsy (FNAB) and who underwent thyroid surgery in our clinic between 2016 and 2021 were retrospectively analyzed. According to histopathologic features, patients were divided into two groups, malignant and benign, and the relationship with age, gender, and nodule diameter was investigated. Statistical significance between groups was determined using Chi-square and Student t-tests. P value <0.05 was accepted. Results The mean age was 47.9±12 years (range, 20-81). The malignancy rate was 43.5%. Malignancy was detected in 42.1% of females and 50% of males. The mean nodule diameter was 19.1±13.7 mm (range, 1-97 mm). There was no statistically significant difference between gender, age, nodule diameter, and Malignancy (p>0.05). Conclusion According to the Bethesda classification, the malignancy rate for AUS is 15-30%. In our study, the malignancy rate was 43.5%, similar to studies published in our country. Because of the high malignancy rate, total thyroidectomy should be considered an alternative to lobectomy in cases planned for surgery with a diagnosis of AUS.

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