Özet:

Purpose: Data on the forecast of patients with interstitial lungs disease (IAH) and treated in the intensive care unit (YBU) due to acute respiratory failure are limited. The mechanical ventilator and respiratory support treatments in the YBU have assessed the characteristics of the IAH events and risk factors affecting mortality. Method and tool: 65 patients (29 K, 36 E) were included in the single-centric, prospective research between January and August 2017. The clinical findings of the incidents in what they were taken, the effects of ventilation support therapies (NIV, IMV) on mortality were studied in their follow-up. Results: Diagnoses found IPF in 34 patients, 13 collagen tissue diseases, 10 acute interstitial pneumonia, 3 Wegener granulomatosis, 2 sarcoidosis, 1 chronic hypersensitivity pneumonia, 1 drug-related lung disease, 1 patient plöroparankimal fibroelastosis. 43 (6.1% of the patient was ex in the YBU. In comparison of patients living and not living, the PaO2/FiO2 and GKS were significantly high in the group living. In the one-variant Cox regression analysis, GKS (HR 1,225; 95% CI: [0,783-1,550]; p=0,052), APACHE II (HR 2,845; 95% CI: [1,431-3,751]; p=0,006), PaO2/FiO2 (HR 1,753; 95% CI: [1,169-1,932]; p=0,012), sPAP (HR 1,601; 95% CI: [0,263-1,710]; p=0,031), and IMV needs (HR 8,441; 95% CI: [3,225-12,632]; p<0,001) increased mortality risk in YBU. According to the multi-variable analysis results, PaO2/FiO2 (HR 1,224; 95% CI: [0,832-1,705]; p=0,015), APACHE II (HR 1,956; 95% CI: [1,031-4,216]; p=0,010), and IMV need (HR 7,473; 95% CI: [3,028-9,243]; p<0,001) were independent risk factors for mortality. The result: acute respiratory failure associated with IAH is a high mortality in patients receiving HIV, and the need for PaO2/FiO2, APACHE II and IMV are the most important risk factors for mortality.

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