Abstract:

Diabetes mellitus is a metabolic disease that affects an imminent part of the world’s population. Arum rupicola, in Eastern and Southeast Anatolia, is used for the treatment of diabetes in public medicine. This study is designed to evaluate the effect of Arum rupicola on the oxidative stress indicators of overground root and body liophlyse extract in diabetic rats created with streptozotonin (STZ). According to the experimental modeling of the study, a total of 36 male rats were randomly divided into six groups. The first group, normal control (NK), the second group of streptozotosin (STZ) experimental diabetes (DK) was created. The third group was given during the standard drug- akarboz (DAK) test period. The fourth, fifth and sixth groups of rats, after developing diabetes with STZ, are 100, 200 and 400 mg/kg respectively (DAR 100, DAR 200, DAR 400 mg/kg). In the dosage range, the Arum rupicola lioflize extract was given to mice. In this study, the levels of superoxidant dismutase (SOD), glutation peroxidase (GPx), catalase (CAT) and non-enzymatic antioxidant glutation (GSH) were measured from elements of the antioxidant defense system. Also, the final product of lipid peroxidation (LPO) has been measured the content of malondaldehyde (MDA). In diabetic groups, reductions in SOD, GPx and CAT and GSH levels in all the doses were found significant according to the normal control (NK) group. However, the reduction in the level of MDA resulting from lipite peroxidation in erythrosite and liver tissues was found significant compared to the normal control and diabetes control groups (p≤0.05). On the other hand, increased MDA levels in the brain tissue group DAR3 and in the kidney tissue group DAR1, DAR2, DAR3 have been statically significant. In the diabetic groups applied plant extracts, the variable SOD, GPx and CAT activity and measurements of GSH determined in different tissues were statistically meaningful (p≤0.05). As a result, Arum rupicola can be said that the plant extract applied against oxidative stress in diabetic rats has an antioxidant effect that differs from tissue to tissue according to the dose range.

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