Özet:

The novel human coronavirus, called SARS-CoV-2, first appeared in late 2019 in Wuhan, causing a respiratory disease termed COVID-19 in China and has been declared a pandemic worldwide. Although many different vaccine development studies against SARS-CoV-2 have reached the final stage, the protection that these vaccines will provide to society is not known for now, and therefore, effective antiviral drugs should be developed. In this study, the effects of the phenolic acids found in Corylus avellana L. on SARS-CoV-2 Main protease (Mpro) was investigated by molecular docking analysis. Also, the pharmacophore properties, biological properties, pharmacokinetics and drug-likeness properties of the compounds examined in the study were evaluated. Molecular docking of Mpro and phenolic acids was done with Autodock Vina. Many of the phenolic acids investigated in the study have interacted with the active site and catalytic residues of the Mpro. Drug similarity of phenolic acids interacting with MPro and each of the interacting compounds were found to be potential target inhibitors against SARS-CoV-2 Mpro and it was determined that its use would have limited or no side effect on the body.

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