Özet:

INTRODUCTION: Tumor-associated inflammation is an important feature of tumor development and progression. We aimed to investigate whether the clinicopathological and prognostic characteristics of patients with classical Hodgkin lymphoma (cHL) were associated with systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). METHODS: This was a retrospective cohort study conducted between January 2012 and December 2021. A total of 77 patients with newly diagnosed cHL were included in the study. RESULTS: The median age of the patients was 37 (24-49) years. Patients with stage IV disease (p=0.036), B symptoms (p=0.005), and extranodal involvement (p=0.012) had significantly higher NLR. Female patients (p=0.005), those with B symptoms (p=0.014) and subjects with extranodal involvement (p=0.011) had significantly higher PLR. Also, the SII of patients with B symptoms was significantly higher compared to those without (p=0.009). There were significant but weak correlations between international prognostic score-7 and SII (r=0.271, p=0.017), PLR (r=0.294, p=0.010) and NLR (r=0.378, p=0.001). DISCUSSION AND CONCLUSION: SII was associated with B symptoms, but was not prognostic for cHL. PLR and NLR were also unassociated with prognosis in patients with cHL. However, considering the exceedingly limited data on this topic, further studies to assess inflammation indices are necessary.

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